Please use this identifier to cite or link to this item: doi:10.22028/D291-29972
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Title: Effect of spectrin network elasticity on the shapes of erythrocyte doublets
Author(s): Hoore, Masoud
Yaya, François
Podgorski, Thomas
Wagner, Christian
Gompper, Gerhard
Fedosov, Dmitry A.
Language: English
Title: Soft matter
Volume: 14
Issue: 30
Startpage: 6278
Endpage: 6289
Publisher/Platform: RSC
Year of Publication: 2018
Publikation type: Journal Article
Abstract: Red blood cell (RBC) aggregates play an important role in determining blood rheology. RBCs in plasma or polymer solution interact attractively to form various shapes of RBC doublets, where the attractive interactions can be varied by changing the solution conditions. A systematic numerical study on RBC doublet formation is performed, which takes into account the shear elasticity of the RBC membrane due to the spectrin cytoskeleton, in addition to the membrane bending rigidity. RBC membranes are modeled by two-dimensional triangular networks of linked vertices, which represent three-dimensional cell shapes. The phase space of RBC doublet shapes in a wide range of adhesion strengths, reduced volumes, and shear elasticities is obtained. The shear elasticity of the RBC membrane changes the doublet phases significantly. Experimental images of RBC doublets in different solutions show similar configurations. Furthermore, we show that rouleau formation is affected by the doublet structure.
DOI of the first publication: 10.1039/C8SM00634B
URL of the first publication: https://pubs.rsc.org/en/content/articlelanding/2018/sm/c8sm00634b#!divAbstract
Link to this record: hdl:20.500.11880/28360
http://dx.doi.org/10.22028/D291-29972
ISSN: 1744-6848
1744-683X
Date of registration: 22-Nov-2019
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Physik
Professorship: NT - Prof. Dr. Christian Wagner
Collections:UniBib – Die Universitätsbibliographie

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