Please use this identifier to cite or link to this item: doi:10.22028/D291-29969
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Title: Antimargination of Microparticles and Platelets in the Vicinity of Branching Vessels
Author(s): Bächer, Christian
Kihm, Alexander
Schrack, Lukas
Kaestner, Lars
Laschke, Matthias W.
Wagner, Christian
Gekle, Stephan
Language: English
Title: Biophysical journal : BJ
Volume: 115
Issue: 2
Startpage: 411
Endpage: 425
Publisher/Platform: Cell Press
Year of Publication: 2018
Publikation type: Journal Article
Abstract: We investigate the margination of microparticles/platelets in blood flow through complex geometries typical for in vivo vessel networks: a vessel confluence and a bifurcation. Using three-dimensional lattice Boltzmann simulations, we confirm that behind the confluence of two vessels, a cell-free layer devoid of red blood cells develops in the channel center. Despite its small size of roughly 1 μm, this central cell-free layer persists for up to 100 μm after the confluence. Most importantly, we show from simulations that this layer also contains a significant amount of microparticles/platelets and validate this result by in vivo microscopy in mouse venules. At bifurcations, however, a similar effect does not appear, and margination is largely unaffected by the geometry. This antimargination toward the vessel center after a confluence may explain earlier in vivo observations, which found that platelet concentrations near the vessel wall are seen to be much higher on the arteriolar side (containing bifurcations) than on the venular side (containing confluences) of the vascular system.
DOI of the first publication: 10.1016/j.bpj.2018.06.013
URL of the first publication: https://www.sciencedirect.com/science/article/pii/S0006349518306891
Link to this record: hdl:20.500.11880/28357
http://dx.doi.org/10.22028/D291-29969
ISSN: 1542-0086
0523-6800
Date of registration: 22-Nov-2019
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Physik
Professorship: NT - Prof. Dr. Christian Wagner
Collections:UniBib – Die Universitätsbibliographie

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