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|Title:||Antimargination of Microparticles and Platelets in the Vicinity of Branching Vessels|
Laschke, Matthias W.
|Title:||Biophysical journal : BJ|
|Year of Publication:||2018|
|Publikation type:||Journal Article|
|Abstract:||We investigate the margination of microparticles/platelets in blood flow through complex geometries typical for in vivo vessel networks: a vessel confluence and a bifurcation. Using three-dimensional lattice Boltzmann simulations, we confirm that behind the confluence of two vessels, a cell-free layer devoid of red blood cells develops in the channel center. Despite its small size of roughly 1 μm, this central cell-free layer persists for up to 100 μm after the confluence. Most importantly, we show from simulations that this layer also contains a significant amount of microparticles/platelets and validate this result by in vivo microscopy in mouse venules. At bifurcations, however, a similar effect does not appear, and margination is largely unaffected by the geometry. This antimargination toward the vessel center after a confluence may explain earlier in vivo observations, which found that platelet concentrations near the vessel wall are seen to be much higher on the arteriolar side (containing bifurcations) than on the venular side (containing confluences) of the vascular system.|
|DOI of the first publication:||10.1016/j.bpj.2018.06.013|
|URL of the first publication:||https://www.sciencedirect.com/science/article/pii/S0006349518306891|
|Link to this record:||hdl:20.500.11880/28357|
|Date of registration:||22-Nov-2019|
|Faculty:||NT - Naturwissenschaftlich- Technische Fakultät|
|Department:||NT - Physik|
|Professorship:||NT - Prof. Dr. Christian Wagner|
|Collections:||UniBib – Die Universitätsbibliographie|
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