Please use this identifier to cite or link to this item: doi:10.22028/D291-29490
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Title: Photoactivatable Adhesive Ligands for Light-Guided Neuronal Growth
Author(s): Farrukh, Aleeza
Fan, Wenqiang
Zhao, Shifang
Salierno, Marcelo
Paez, Julieta I.
del Campo Bécares, Aránzazu
Language: English
Title: ChemBioChem : a European journal of chemical biology
Volume: 19
Issue: 12
Startpage: 1271
Endpage: 1279
Publisher/Platform: Wiley-VCH
Year of Publication: 2018
Publikation type: Journal Article
Abstract: Neuro-regeneration after trauma requires growth and reconnection of neurons to reestablish information flow in particular directions across the damaged tissue. To support this process, biomaterials for nerve tissue regeneration need to provide spatial information to adhesion receptors on the cell membrane and to provide directionality to growing neurites. Here, photoactivatable adhesive peptides based on the CASIKVAVSADR laminin peptidomimetic are presented and applied to spatiotemporal control of neuronal growth to biomaterials in vitro. The introduction of a photoremovable group [6-nitroveratryl (NVOC), 3-(4,5-dimethoxy-2-nitrophenyl)butan-2-yl (DMNPB), or 2,2'-((3'-(1-hydroxypropan-2-yl)-4'-nitro-[1,1'-biphenyl]-4-yl)azanediyl)bis(ethan-1-ol) (HANBP)] at the amino terminal group of the K residue temporally inhibited the activity of the peptide. The bioactivity was regained through controlled light exposure. When used in neuronal culture substrates, the peptides allowed light-based control of the attachment and differentiation of neuronal cells. Site-selective irradiation activated adhesion and differentiation cues and guided seeded neurons to grow in predefined patterns. This is the first demonstration of ligand-based light-controlled interaction between neuronal cells and biomaterials.
DOI of the first publication: 10.1002/cbic.201800118
URL of the first publication:
Link to this record: hdl:20.500.11880/28225
ISSN: 1439-7633
Date of registration: 28-Oct-2019
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Chemie
Professorship: NT - Prof. Dr. Aránzazu del Campo
Collections:UniBib – Die Universitätsbibliographie

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