Please use this identifier to cite or link to this item: doi:10.22028/D291-29492
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Title: In Situ, Light-Guided Axon Growth on Biomaterials via Photoactivatable Laminin Peptidomimetic IK(HANBP)VAV
Author(s): Farrukh, Aleeza
Zhao, Shifang
Paez, Julieta I.
Kavyanifar, Atria
Salierno, Marcelo
Cavalié, Adolfo
del Campo Bécares, Aránzazu
Language: English
Title: ACS applied materials & interfaces
Volume: 10
Issue: 48
Startpage: 41129
Endpage: 41137
Publisher/Platform: ACS
Year of Publication: 2018
Publikation type: Journal Article
Abstract: The ability to guide the growth of neurites is relevant for reconstructing neural networks and for nerve tissue regeneration. Here, a biofunctional hydrogel that allows light-based directional control of axon growth in situ is presented. The gel is covalently modified with a photoactivatable derivative of the short laminin peptidomimetic IKVAV. This adhesive peptide contains the photoremovable group 2-(4'-amino-4-nitro-[1,1'-biphenyl]-3-yl)propan-1-ol (HANBP) on the Lys rest that inhibits its activity. The modified peptide is highly soluble in water and can be simply conjugated to -COOH containing hydrogels via its terminal -NH2 group. Light exposure allows presentation of the IKVAV adhesive motif on a soft hydrogel at desired concentration and at defined position and time point. The photoactivated gel supports neurite outgrowth in embryonic neural progenitor cells culture and allows site-selective guidance of neurites extension. In situ exposure of cell cultures using a scanning laser allows outgrowth of neurites in desired pathways.
DOI of the first publication: 10.1021/acsami.8b15517
URL of the first publication: https://pubs.acs.org/doi/10.1021/acsami.8b15517
Link to this record: hdl:20.500.11880/28210
http://dx.doi.org/10.22028/D291-29492
ISSN: 1944-8252
1944-8244
Date of registration: 25-Oct-2019
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Chemie
Professorship: NT - Prof. Dr. Aránzazu del Campo
Collections:UniBib – Die Universitätsbibliographie

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