Please use this identifier to cite or link to this item: doi:10.22028/D291-29501
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Title: Microenvironments to study migration and somal translocation in cortical neurons
Author(s): Zhao, Shifang
Fan, Wenqiang
Guo, Xiang
Xue, Longjian
Berninger, Benedikt
Salierno, Marcelo J.
del Campo Bécares, Aránzazu
Language: English
Title: Biomaterials
Volume: 156
Startpage: 238
Endpage: 247
Publisher/Platform: Elsevier
Year of Publication: 2018
Publikation type: Journal Article
Abstract: Migrating post-mitotic neurons of the developing cerebral cortex undergo terminal somal translocation (ST) when they reach their final destination in the cortical plate. This process is crucial for proper cortical layering and its perturbation can lead to brain dysfunction. Here we present a reductionist biomaterials platform that faithfully supports and controls the distinct phases of terminal ST in vitro. We developed microenvironments with different adhesive molecules to support neuronal attachment, neurite extension, and migration in distinct manners. Efficient ST occurred when the leading process of migratory neurons crossed from low-to high-adhesive areas on a substrate, promoting spreading of the leading growth cone. Our results indicate that elementary adhesive cell-substrate interactions strongly influence migratory behavior and the final positioning of neurons during their developmental journey. This in vitro model allows advanced experimentation to reveal the microenvironmental requirements underlying cortical layer development and disorders.
DOI of the first publication: 10.1016/j.biomaterials.2017.11.042
URL of the first publication:
Link to this record: hdl:20.500.11880/28204
ISSN: 0142-9612
Date of registration: 25-Oct-2019
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Chemie
Professorship: NT - Prof. Dr. Aránzazu del Campo
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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