Please use this identifier to cite or link to this item: doi:10.22028/D291-29509
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Title: Optoregulated Drug Release from an Engineered Living Material: Self-Replenishing Drug Depots for Long-Term, Light-Regulated Delivery
Author(s): Sankaran, Shrikrishnan
Becker, Judith
Wittmann, Christoph
del Campo Bécares, Aránzazu
Language: English
Title: Small : nano micro
Volume: 15
Issue: 5
Publisher/Platform: Wiley-VCH
Year of Publication: 2019
Publikation type: Journal Article
Abstract: On-demand and long-term delivery of drugs are common requirements in many therapeutic applications, not easy to be solved with available smart polymers for drug encapsulation. This work presents a fundamentally different concept to address such scenarios using a self-replenishing and optogenetically controlled living material. It consists of a hydrogel containing an active endotoxin-free Escherichia coli strain. The bacteria are metabolically and optogenetically engineered to secrete the antimicrobial and antitumoral drug deoxyviolacein in a light-regulated manner. The permeable hydrogel matrix sustains a viable and functional bacterial population and permits diffusion and delivery of the synthesized drug to the surrounding medium at quantities regulated by light dose. Using a focused light beam, the site for synthesis and delivery of the drug can be freely defined. The living material is shown to maintain considerable levels of drug production and release for at least 42 days. These results prove the potential and flexibility that living materials containing engineered bacteria can offer for advanced therapeutic applications.
DOI of the first publication: 10.1002/smll.201804717
URL of the first publication: https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.201804717
Link to this record: hdl:20.500.11880/28200
http://dx.doi.org/10.22028/D291-29509
ISSN: 1613-6829
1613-6810
Date of registration: 25-Oct-2019
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Chemie
Professorship: NT - Prof. Dr. Aránzazu del Campo
Collections:UniBib – Die Universitätsbibliographie

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