Please use this identifier to cite or link to this item: doi:10.22028/D291-29491
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Title: Microenvironments Designed to Support Growth and Function of Neuronal Cells
Author(s): Farrukh, Aleeza
Zhao, Shifang
del Campo Bécares, Aránzazu
Language: English
Title: Frontiers in Materials
Volume: 5
Startpage: 1
Endpage: 22
Publisher/Platform: Frontiers
Year of Publication: 2018
Publikation type: Journal Article
Abstract: Strategies for neural tissue repair heavily depend on our ability to temporally reconstruct the natural cellular microenvironment of neural cells. Biomaterials play a fundamental role in this context, as they provide the mechanical support for cells to attach and migrate to the injury site, as well as fundamental signals for differentiation. This review describes how different cellular processes (attachment, proliferation, and (directional) migration and differentiation) have been supported by different material parameters, in vitro and in vivo. Although incipient guidelines for biomaterial design become visible, literature in the field remains rather phenomenological. As in other fields of tissue regeneration, progress will depend on more systematic studies on cell-materials response, better understanding on how cells behave and understand signals in their natural milieu from neurobiology studies, and the translation of this knowledge into engineered microenvironments for clinical use.
DOI of the first publication: 10.3389/fmats.2018.00062
URL of the first publication:
Link to this record: hdl:20.500.11880/28193
ISSN: 2296-8016
Date of registration: 25-Oct-2019
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Chemie
Professorship: NT - Prof. Dr. Aránzazu del Campo
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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