Please use this identifier to cite or link to this item: doi:10.22028/D291-29471
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Title: A Self-Adhesive Elastomeric Wound Scaffold for Sensitive Adhesion to Tissue
Author(s): Boyadzhieva, Silviya
Sorg, Katharina
Danner, Martin
Fischer, Sarah C. L.
Hensel, René
Schick, Bernhard
Wenzel, Gentiana
Arzt, Eduard
Kruttwig, Klaus
Language: English
Title: Polymers
Volume: 11
Issue: 6
Publisher/Platform: MDPI
Year of Publication: 2019
Publikation type: Journal Article
Abstract: Pressure sensitive adhesives based on silicone materials are used particularly for skin adhesion, e.g., the fixation of electrocardiogram (ECG) electrodes or wound dressings. However, adhesion to sensitive tissue structures is not sufficiently addressed due to the risk of damage or rupture. We propose an approach in which a poly-(dimethylsiloxane) (PDMS)-based soft skin adhesive (SSA) acts as cellular scaffold for wound healing. Due to the intrinsically low surface free energy of silicone elastomers, functionalization strategies are needed to promote the attachment and spreading of eukaryotic cells. In the present work, the effect of physical adsorption of three different proteins on the adhesive properties of the soft skin adhesive was investigated. Fibronectin adsorption slightly affects adhesion but significantly improves the cellular interaction of L929 murine fibroblasts with the polymeric surface. Composite films were successfully attached to explanted tympanic membranes. This demonstrates the potential of protein functionalized SSA to act as an adhesive scaffold in delicate biomedical applications.
DOI of the first publication: 10.3390/polym11060942
Link to this record: hdl:20.500.11880/28156
ISSN: 2073-4360
Date of registration: 21-Oct-2019
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Materialwissenschaft und Werkstofftechnik
Professorship: NT - Prof. Dr. Eduard Arzt
Collections:UniBib – Die Universitätsbibliographie

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