Please use this identifier to cite or link to this item: doi:10.22028/D291-29626
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Title: In vivo multiphoton microscopy of melasma.
Author(s): Lentsch, Griffin
Balu, Mihaela
Williams, Joshua
Lee, Sanghoon
Harris, Ronald M.
König, Karsten
Ganesan, Anand
Tromberg, Bruce J.
Nair, Nirmala
Santhanam, Uma
Misra, Manoj
Language: English
Title: Pigment Cell and Melanoma Research
Volume: 32
Issue: 3
Startpage: 403
Endpage: 411
Publisher/Platform: Wiley-Blackwell - STM
Year of Publication: 2019
Publikation type: Journal Article
Abstract: Melasma is a skin disorder characterized by hyperpigmented patches due to increased melanin production and deposition. In this pilot study, we evaluate the potential of multiphoton microscopy (MPM) to characterize non-invasively the melanin content, location, and distribution in melasma and assess the elastosis severity. We employed a clinical MPM tomograph to image in vivo morphological features in melasma lesions and adjacent normal skin in 12 patients. We imaged dermal melanophages in most dermal melasma lesions and occasionally in epidermal melasma. The melanin volume fraction values measured in epidermal melasma (14% ± 4%) were significantly higher (p < 0.05) than the values measured in perilesional skin (11% ± 3%). The basal keratinocytes of melasma and perilesions showed different melanin distribution. Elastosis was predominantly more severe in lesions than in perilesions and was associated with changes in melanin distribution of the basal keratinocytes. These results demonstrate that MPM may be a non-invasive imaging tool for characterizing melasma.
DOI of the first publication: 10.1111/pcmr.12756
Link to this record: hdl:20.500.11880/28012
ISSN: 1600-0749
Date of registration: 7-Oct-2019
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Systems Engineering
Professorship: NT - Prof. Dr. Karsten König
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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