Please use this identifier to cite or link to this item: doi:10.22028/D291-29609
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Title: Ciprofloxacin-loaded lipid-core nanocapsules as mucus penetrating drug delivery system intended for the treatment of bacterial infections in cystic fibrosis
Author(s): Torge, Afra
Wagner, Stefanie
Chaves, Paula S.
Oliveira, Edilene G.
Guterres, Silvia S.
Pohlmann, Adriana R.
Titz, Alexander
Schneider, Marc
Beck, Ruy C. R.
Language: English
Title: International journal of pharmaceutics
Volume: 527
Issue: 1-2
Startpage: 92
Endpage: 102
Publisher/Platform: Elsevier
Year of Publication: 2017
Publikation type: Journal Article
Abstract: Treatment of bacterial airway infections is essential for cystic fibrosis therapy. However, effectiveness of antibacterial treatment is limited as bacteria inside the mucus are protected from antibiotics and immune response. To overcome this biological barrier, ciprofloxacin was loaded into lipid-core nanocapsules (LNC) for high mucus permeability, sustained release and antibacterial activity. Ciprofloxacin-loaded LNC with a mean size of 180nm showed a by 50% increased drug permeation through mucus. In bacterial growth assays, the drug in the LNC had similar minimum inhibitory concentrations as the free drug in P. aeruginosa and S. aureus. Interestingly, formation of biofilm-like aggregates, which were observed for S. aureus treated with free ciprofloxacin, was avoided by exposure to LNC. With the combined advantages over the non-encapsulated drug, ciprofloxacin-loaded LNC represent a promising drug delivery system with the prospect of an improved antibiotic therapy in cystic fibrosis.
DOI of the first publication: 10.1016/j.ijpharm.2017.05.013
URL of the first publication: https://www.sciencedirect.com/science/article/pii/S0378517317304234
Link to this record: hdl:20.500.11880/27994
http://dx.doi.org/10.22028/D291-29609
ISSN: 1873-3476
0378-5173
Date of registration: 1-Oct-2019
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Pharmazie
Professorship: NT - Prof. Dr. Marc Schneider
Collections:UniBib – Die Universitätsbibliographie

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