Please use this identifier to cite or link to this item: doi:10.22028/D291-29602
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Title: Shortwave Infrared in Vivo Imaging with Gold Nanoclusters
Author(s): Chen, Yue
Montana, Daniel M.
Wei, He
Cordero, Jose M.
Schneider, Marc
Le Guével, Xavier
Chen, Ou
Bruns, Oliver T.
Bawendi, Moungi G.
Language: English
Title: Nano Letters
Volume: 17
Issue: 10
Startpage: 6330
Endpage: 6334
Publisher/Platform: American Chemical Society (ACS)
Year of Publication: 2017
Publikation type: Journal Article
Abstract: The use of visible/NIR-emitting gold nanoclusters (Au NCs), previously proposed for in vivo imaging, has been limited to some extent by low quantum yields (QYs) and the limited penetration of visible light in tissue. Here we report short wavelength infrared (SWIR, λ = 1-2 μm) emitting Au NCs with a good photoluminescence QY for this wavelength range (0.6% to 3.8% for λem = 1000 to 900 nm) and excellent stability under physiological conditions. We show that surface ligand chemistry is critical to achieving these properties. We demonstrate the potential of these SWIR-emitting Au NCs for in vivo imaging in mice. The Au NCs have a hydrodynamic diameter that is small (∼5 nm) enough that they exhibit a rapid renal clearance, and images taken in the SWIR region show better resolution of the blood vessels than in the NIR region.
DOI of the first publication: 10.1021/acs.nanolett.7b03070
Link to this record: hdl:20.500.11880/27987
ISSN: 1530-6992
Date of registration: 1-Oct-2019
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Pharmazie
Professorship: NT - Prof. Dr. Marc Schneider
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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