Please use this identifier to cite or link to this item: doi:10.22028/D291-29599
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Title: Stabilized tetraether lipids based particles guided prophyrins photodynamic therapy
Author(s): Mahmoud, Gihan
Jedelská, Jarmila
Omar, Samia Mohamed
Strehlow, Boris
Schneider, Marc
Bakowsky, Udo
Language: English
Title: Drug delivery : the journal of delivery and targeting of therapeutic agents
Volume: 25
Issue: 1
Startpage: 1526
Endpage: 1536
Publisher/Platform: Taylor & Francis
Year of Publication: 2018
Publikation type: Journal Article
Abstract: Photodynamic therapy (PDT) that involves ergonomically delivered light in the presence of archetypical photosensitizer such as Protoporphyrin IX (PpIX) is a time-honored missile strategy in cancer therapeutics. Yet, the premature release of PpIX is one of the most abundant dilemma encounters the therapeutic outcomes of PDT due to associated toxicity and redistribution to serum proteins. In this study, ultrastable tetraether lipids (TELs) based liposomes were developed. PpIX molecules were identified to reside physically in the monolayer; thereby the inherent π-π stacking that leads to aggregation of PpIX in aqueous milieu was dramatically improved. TEL29.9 mol% and TEL62mol% based liposomes revealed PpIX sustained release diffusion pattern from spherical particles as confirmed by converged fitting to Baker & Lonsdale model. Stability in presence of human serum albumins, a key element for PDT accomplishment was emphasized. The epitome candidates were selected for vascular photodynamic (vPDT) in in-Ovo chick chorioallantoic membrane. Profoundly, TEL62mol% based liposomes proved to be the most effective liposomes that demonstrated localized effect within the irradiated area without eliciting quiescent vasculatures damages. Cellular photodynamic therapy (cPDT) revealed that various radiant exposure doses of 134, 202, 403 or 672 could deliberately modulate the photo-responses of PpIX in TEL-liposomes.
DOI of the first publication: 10.1080/10717544.2018.1482970
URL of the first publication:
Link to this record: hdl:20.500.11880/27984
ISSN: 1521-0464
Date of registration: 1-Oct-2019
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Pharmazie
Professorship: NT - Prof. Dr. Marc Schneider
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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