Please use this identifier to cite or link to this item: doi:10.22028/D291-29595
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Title: Nano spray dried antibacterial coatings for dental implants
Author(s): Baghdan, Elias
Raschpichler, Michael
Lutfi, Walaa
Pinnapireddy, Shashank Reddy
Pourasghar, Marcel
Schäfer, Jens
Schneider, Marc
Bakowsky, Udo
Language: English
Title: European journal of pharmaceutics and biopharmaceutics : EJPB
Volume: 139
Startpage: 59
Endpage: 67
Publisher/Platform: Elsevier
Year of Publication: 2019
Publikation type: Journal Article
Abstract: Nanostructured coatings of dental implants have shown great potential in overcoming many challenges responsible for implant failure. In this study, nano spray drying technology was utilized to produce novel biocompatible nanocoatings with antibacterial activity. The experiments were applied on titanium discs, which were used as a model material for dental implants. The produced nanocoatings consisted of poly(lactic-co-glycolic acid) as a biodegradable polymer and norfloxacin as a model antibiotic. Scanning electron microscopy results revealed an average particle size ranging between 400 and 600 nm. In vitro release studies showed a biphasic drug release profile with a burst release within the first 48 h, followed by a sustained release phase until the end of the experiment. The antibacterial activity of the nanocoatings was evaluated against Escherichia coli where the norfloxacin loaded nanocoatings achieved up to 99.83% reduction in the number of viable bacterial colonies. Finally, in vitro biocompatibility of the nanocoatings was investigated using mouse fibroblasts (L929) as a standard sensitive cell line for cytotoxicity assessment. Cell proliferation on the surface of the titanium discs was studied using fluorescence microscopy followed by cell counting assay. Both methods confirmed the biocompatibility of the examined nanocoatings. In conclusion, nano spray drying is a promising technique for preparing tailor-made nanocoatings, thereby representing an innovative approach for the surface modification of dental implants.
DOI of the first publication: 10.1016/j.ejpb.2019.03.003
URL of the first publication: https://www.sciencedirect.com/science/article/abs/pii/S0939641119301043
Link to this record: hdl:20.500.11880/27981
http://dx.doi.org/10.22028/D291-29595
ISSN: 1873-3441
0931-8070
0939-6411
Date of registration: 1-Oct-2019
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Pharmazie
Professorship: NT - Prof. Dr. Marc Schneider
Collections:UniBib – Die Universitätsbibliographie

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