Please use this identifier to cite or link to this item: doi:10.22028/D291-29574
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Title: Evaluation of novel organosilane modifications of paper spray mass spectrometry substrates for analyzing polar compounds
Author(s): Bambauer, Thomas P.
Maurer, Hans H.
Weber, Armin A.
Hannig, Matthias
Pütz, Norbert
Koch, Marcus
Manier, Sascha K.
Schneider, Marc
Meyer, Markus R.
Language: English
Title: Talanta : the international journal of pure and applied analytical chemistry
Volume: 204
Startpage: 677
Endpage: 684
Publisher/Platform: Elsevier
Year of Publication: 2019
Publikation type: Journal Article
Abstract: Paper spray mass spectrometry (PSMS) is currently used in different analytical fields, but less effort has been made so far to use PSMS for highly polar compounds. Such analytes usually show poor performance in PSMS due to their high affinity for common paper substrates in addition to high matrix effects. In this study, strategies for hydrophobic modifications of commercially available paper substrates using ten different organosilanes were developed. The modified substrates were generated, characterized, and applied for PSMS analysis of polar toxins. By using the modified paper, PSMS performance of some of the toxins could be considerably increased, especially for orellanine, showing a more than 80-fold signal enhancement when substrates modified with chlorotrimethylsilane were used. For other toxins like ricinine, only small beneficial effects could be shown on PSMS performance when using modified substrates. Statistical equivalence tests showed sufficient ruggedness of the developed procedures also compared to conventional substrates. Thus, further systematic development of paper substrates modified with organosilane derivatives based on the presented study for application in PSMS should be encouraged.
DOI of the first publication: 10.1016/j.talanta.2019.05.095
URL of the first publication: https://www.sciencedirect.com/science/article/abs/pii/S0039914019305892
Link to this record: hdl:20.500.11880/27968
http://dx.doi.org/10.22028/D291-29574
ISSN: 1873-3573
0039-9140
Date of registration: 30-Sep-2019
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Pharmazie
Professorship: NT - Prof. Dr. Marc Schneider
Collections:UniBib – Die Universitätsbibliographie

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