Please use this identifier to cite or link to this item: doi:10.22028/D291-29536
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Title: DNA methylation alterations in iPSC- and hESC-derived neurons : potential implications for neurological disease modeling
Author(s): de Boni, Laura
Gasparoni, Gilles
Haubenreich, Carolin
Tierling, Sascha
Schmitt, Ina
Peitz, Michael
Koch, Philipp
Walter, Jörn Erik
Wüllner, Ullrich
Brüstle, Oliver
Language: English
Title: Clinical epigenetics
Volume: 10
Issue: 13
Publisher/Platform: BioMed Central
Year of Publication: 2018
Publikation type: Journal Article
Abstract: Genetic predisposition and epigenetic alterations are both considered to contribute to sporadic neurodegenerative diseases (NDDs) such as Parkinson's disease (PD). Since cell reprogramming and the generation of induced pluripotent stem cells (iPSCs) are themselves associated with major epigenetic remodeling, it remains unclear to what extent iPSC-derived neurons lend themselves to model epigenetic disease-associated changes. A key question to be addressed in this context is whether iPSC-derived neurons exhibit epigenetic signatures typically observed in neurons derived from non-reprogrammed human embryonic stem cells (hESCs).
DOI of the first publication: 10.1186/s13148-018-0440-0
Link to this record: hdl:20.500.11880/27923
http://dx.doi.org/10.22028/D291-29536
ISSN: 1868-7075
1868-7083
Date of registration: 26-Sep-2019
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Biowissenschaften
Professorship: NT - Prof. Dr. Jörn Walter
Collections:UniBib – Die Universitätsbibliographie

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