Please use this identifier to cite or link to this item: doi:10.22028/D291-29531
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Title: Exposure to the gut microbiota drives distinct methylome and transcriptome changes in intestinal epithelial cells during postnatal development
Author(s): Pan, Wei-Hung
Sommer, Felix
Falk-Paulsen, Maren
Ulas, Thomas
Best, Philipp
Fazio, Antonella
Kachroo, Priyadarshini
Luzius, Anne
Jentzsch, Marlene
Rehman, Ateequr
Müller, Fabian
Lengauer, Thomas
Walter, Jörn Erik
Künzel, Sven
Baines, John F.
Schreiber, Stefan
Franke, Andre
Schultze, Joachim L.
Bäckhed, Fredrik
Rosenstiel, Philip
Language: English
Title: Genome medicine
Volume: 10
Issue: 1
Publisher/Platform: BioMed Central
Year of Publication: 2018
Publikation type: Journal Article
Abstract: The interplay of epigenetic processes and the intestinal microbiota may play an important role in intestinal development and homeostasis. Previous studies have established that the microbiota regulates a large proportion of the intestinal epithelial transcriptome in the adult host, but microbial effects on DNA methylation and gene expression during early postnatal development are still poorly understood. Here, we sought to investigate the microbial effects on DNA methylation and the transcriptome of intestinal epithelial cells (IECs) during postnatal development.
DOI of the first publication: 10.1186/s13073-018-0534-5
Link to this record: hdl:20.500.11880/27919
http://dx.doi.org/10.22028/D291-29531
ISSN: 1756-994X
Date of registration: 26-Sep-2019
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Biowissenschaften
Professorship: NT - Prof. Dr. Jörn Walter
Collections:UniBib – Die Universitätsbibliographie

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