Please use this identifier to cite or link to this item: doi:10.22028/D291-29520
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Title: Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
Author(s): Brosch, Mario
Kattler, Kathrin
Herrmann, Alexander
von Schönfels, Witigo
Nordström, Karl
Seehofer, Daniel
Damm, Georg
Becker, Thomas
Zeissig, Sebastian
Nehring, Sophie
Reichel, Fabian
Moser, Vincent
Thangapandi, Raghavan Veera
Stickel, Felix
Baretton, Gustavo
Röcken, Christoph
Muders, Michael
Matz-Soja, Madlen
Krawczak, Michael
Gasparoni, Gilles
Hartmann, Hella
Dahl, Andreas
Schafmayer, Clemens
Walter, Jörn Erik
Hampe, Jochen
Language: English
Title: Nature communications
Volume: 9
Issue: 1
Publisher/Platform: Nature Publishing Group
Year of Publication: 2018
Publikation type: Journal Article
Abstract: A deeper epigenomic understanding of spatial organization of cells in human tissues is an important challenge. Here we report the first combined positional analysis of transcriptomes and methylomes across three micro-dissected zones (pericentral, intermediate and periportal) of human liver. We identify pronounced anti-correlated transcriptional and methylation gradients including a core of 271 genes controlling zonated metabolic and morphogen networks and observe a prominent porto-central gradient of DNA methylation at binding sites of 46 transcription factors. The gradient includes an epigenetic and transcriptional Wnt signature supporting the concept of a pericentral hepatocyte regeneration pathway under steady-state conditions. While donors with non-alcoholic fatty liver disease show consistent gene expression differences corresponding to the severity of the disease across all zones, the relative zonated gene expression and DNA methylation patterns remain unchanged. Overall our data provide a wealth of new positional insights into zonal networks controlled by epigenetic and transcriptional gradients in human liver.
DOI of the first publication: 10.1038/s41467-018-06611-5
Link to this record: hdl:20.500.11880/27908
ISSN: 2041-1723
Date of registration: 26-Sep-2019
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Biowissenschaften
Professorship: NT - Prof. Dr. Jörn Walter
Collections:Die Universitätsbibliographie

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