Please use this identifier to cite or link to this item: doi:10.22028/D291-29454
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Title: CYP4Z1 - A Human Cytochrome P450 Enzyme that Might Hold the Key to Curing Breast Cancer
Author(s): Yang, Xu
Hutter, Michael Christopher
Goh, Wilson Wen Bin
Bureik, Matthias
Language: English
Title: Current pharmaceutical design : a timely review journal on recent advances in drug design
Volume: 23
Issue: 14
Startpage: 2060
Endpage: 2064
Publisher/Platform: Bentham Science Publishers
Year of Publication: 2017
Publikation type: Journal Article
Abstract: The human cytochrome P450 (CYP) enzyme CYP4Z1 is a fatty acid hydroxylase which among human CYPs is unique for being much stronger expressed in the mammary gland than in all other tissues. Moreover, it is strongly overexpressed in all subtypes of breast cancer, and some overexpression has also been found in other types of malignancies, such as ovarian, lung, and prostate cancers, respectively. Due to its unique expression pattern it is conceivable that this enzymes' activity might be exploited for a new therapeutic approach. However, the main challenge for a CYP4Z1-based prodrug strategy (CBPS) for the treatment of breast cancer (and possibly other CYP4Z1-positive malignancies) is the identification of candidate prodrugs that can be activated by this enzyme. In this mini-review we summarize the current knowledge about the enzymatic properties of the CYP4Z1 enzyme as well as on the expression pattern of the CYP4Z1 gene in both normal and cancer cells. Moreover, we present the first homology model of this enzyme and give an outlook on its potential use in cancer treatment strategies.
DOI of the first publication: 10.2174/1381612823666170207150156
URL of the first publication:
Link to this record: hdl:20.500.11880/27907
ISSN: 1381-6128
Date of registration: 26-Sep-2019
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Biowissenschaften
Professorship: NT - Prof. Dr. Volkhard Helms
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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