Please use this identifier to cite or link to this item: doi:10.22028/D291-29377
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Title: Heterologous expression of bacterial natural product biosynthetic pathways
Author(s): Huo, Liujie
Hug, Joachim Josef
Fu, Chengzhang
Bian, Xiaoying
Zhang, Youming
Müller, Rolf
Language: English
Title: Natural product reports
Volume: 36
Issue: 9
Publisher/Platform: RSC
Year of Publication: 2019
Publikation type: Journal Article
Abstract: Covering: 2013 to June 2018Heterologous expression of natural product biosynthetic pathways is of increasing interest in microbial biotechnology, drug discovery and optimization. It empowers not only the robust production of valuable biomolecules in more amenable heterologous hosts but also permits the generation of novel analogs through biosynthetic engineering. This strategy also facilitates the discovery of novel bioactive compounds following the functional expression of cryptic biosynthetic gene clusters (BGCs) from fastidious original producers or metagenomic DNA in surrogate hosts, thus facilitating genome mining in the post-genomic era. This review discusses recent advances and trends pertaining to the heterologous production of bacterial natural products, with an emphasis on new techniques, heterologous hosts, and novel chemistry since 2013.
DOI of the first publication: 10.1039/c8np00091c
URL of the first publication:!divAbstract
Link to this record: hdl:20.500.11880/27869
ISSN: 0265-0568
Date of registration: 24-Sep-2019
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Pharmazie
Professorship: NT - Prof. Dr. Rolf Müller
Collections:Die Universitätsbibliographie

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