Please use this identifier to cite or link to this item: doi:10.22028/D291-29379
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Title: Concepts and Methods to Access Novel Antibiotics from Actinomycetes
Author(s): Hug, Joachim Josef
Bader, Chantal D.
Remškar, Maja
Cirnski, Katarina
Müller, Rolf
Language: English
Title: Antibiotics
Volume: 7
Issue: 2
Publisher/Platform: MDPI
Year of Publication: 2018
Publikation type: Journal Article
Abstract: Actinomycetes have been proven to be an excellent source of secondary metabolites for more than half a century. Exhibiting various bioactivities, they provide valuable approved drugs in clinical use. Most microorganisms are still untapped in terms of their capacity to produce secondary metabolites, since only a small fraction can be cultured in the laboratory. Thus, improving cultivation techniques to extend the range of secondary metabolite producers accessible under laboratory conditions is an important first step in prospecting underexplored sources for the isolation of novel antibiotics. Currently uncultured actinobacteria can be made available by bioprospecting extreme or simply habitats other than soil. Furthermore, bioinformatic analysis of genomes reveals most producers to harbour many more biosynthetic gene clusters than compounds identified from any single strain, which translates into a silent biosynthetic potential of the microbial world for the production of yet unknown natural products. This review covers discovery strategies and innovative methods recently employed to access the untapped reservoir of natural products. The focus is the order of actinomycetes although most approaches are similarly applicable to other microbes. Advanced cultivation methods, genomics- and metagenomics-based approaches, as well as modern metabolomics-inspired methods are highlighted to emphasise the interplay of different disciplines to improve access to novel natural products.
DOI of the first publication: 10.3390/antibiotics7020044
Link to this record: hdl:20.500.11880/27867
ISSN: 2079-6382
Date of registration: 24-Sep-2019
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Pharmazie
Professorship: NT - Prof. Dr. Rolf Müller
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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