Please use this identifier to cite or link to this item: doi:10.22028/D291-28967
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Title: Metastable Prepores in Tension-Free Lipid Bilayers
Author(s): Ting, Christina L.
Awasthi, Neha
Müller, Marcus
Hub, Jochen Sebastian
Language: English
Title: Physical review letters
Volume: 120
Issue: 12
Publisher/Platform: APS
Year of Publication: 2018
Publikation type: Journal Article
Abstract: The formation and closure of aqueous pores in lipid bilayers is a key step in various biophysical processes. Large pores are well described by classical nucleation theory, but the free-energy landscape of small, biologically relevant pores has remained largely unexplored. The existence of small and metastable "prepores" was hypothesized decades ago from electroporation experiments, but resolving metastable prepores from theoretical models remained challenging. Using two complementary methods-atomistic simulations and self-consistent field theory of a minimal lipid model-we determine the parameters for which metastable prepores occur in lipid membranes. Both methods consistently suggest that pore metastability depends on the relative volume ratio between the lipid head group and lipid tails: lipids with a larger head-group volume fraction (or shorter saturated tails) form metastable prepores, whereas lipids with a smaller head-group volume fraction (or longer unsaturated tails) form unstable prepores.
DOI of the first publication: 10.1103/PhysRevLett.120.128103
URL of the first publication:
Link to this record: hdl:20.500.11880/27789
ISSN: 1079-7114
Date of registration: 17-Sep-2019
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Physik
Professorship: NT - Prof. Dr. Jochen Hub
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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