Please use this identifier to cite or link to this item: doi:10.22028/D291-28878
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Title: Reduced graphene oxide biosensor platform for the detection of NT-proBNP biomarker in its clinical range
Author(s): Munief, Walid-Madhat
Lu, Xiaoling
Teucke, Tobias
Wilhelm, Jannick
Britz, Anette
Hempel, Felix
Lanche, Ruben
Schwartz, Miriam
Law, Jessica Ka Yan
Grandthyll, Samuel
Müller, Frank
Neurohr, Jens-Uwe
Jacobs, Karin
Schmitt, Michael
Pachauri, Vivek
Hempelmann, Rolf
Ingebrandt, Sven
Language: English
Title: Biosensors and Bioelectronics
Volume: 126
Startpage: 136
Endpage: 142
Publisher/Platform: Elsevier
Year of Publication: 2019
Publikation type: Journal Article
Abstract: Reduced graphene oxide (rGO) thin films can be exploited as highly sensitive transducer layers and integrated in interdigital micro-electrode systems for biosensing processes. The distinctive bipolar characterisitics of rGO thin films can be modulated by a very low external electric field due to the electrostatic charges of biomolecules. These charges lead to a fast response in the readout signals of rGO based ion sensitive field-effect transistors (ISFETs). The characterisitc changes of rGO ISFETs enable a fast, accurate and reproducible detection of biomolecules. The biosensing mechanism offers a fast and label-free approach for analyte detection in contrast to the classical ELISA method. In this contribution, we introduce a reproducible fabrication process of rGO based field-effect transistors on wafer level. The sensors are functionalized as biosensors to measure N-terminal pro-brain natriuretic peptide (NT-proBNP) in human serum within its clinical range. Our optimized rGO sensor shows very promising electrical properties and can be considered as a proof of concept study for the detection of various analytes. The easy and cost-effective fabrication as well as the versatile usability make this new technological platform an auspicious tool for different sensing applications in future.
DOI of the first publication: 10.1016/j.bios.2018.09.102
Link to this record: hdl:20.500.11880/27763
ISSN: 09565663
Date of registration: 13-Sep-2019
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Physik
Professorship: NT - Prof. Dr. Karin Jacobs
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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