Please use this identifier to cite or link to this item: doi:10.22028/D291-28867
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Title: Adding phosphorylation events to the core oscillator driving the cell cycle of fission yeast
Author(s): Humaidan, Dania
Breinig, Frank
Helms, Volkhard
Language: English
Title: PLOS ONE
Volume: 13
Issue: 12
Startpage: 1
Endpage: 16
Publisher/Platform: PLOS
Year of Publication: 2018
Publikation type: Journal Article
Abstract: Much is known about the regulatory elements controlling the cell cycle in fission yeast (Schizosaccharomyces pombe). This regulation is mainly done by the (cyclin-dependent kinase/cyclin) complex (Cdc2/Cdc13) that activates specific target genes and proteins via phosphorylation events during the cell cycle in a time-dependent manner. However, more work is still needed to complement the existing gaps in the current fission yeast gene regulatory network to be able to overcome abnormalities in its growth, repair and development, i.e. explain many phenomena including mitotic catastrophe. In this work we complement the previously presented core oscillator of the cell cycle of fission yeast by selected phosphorylation events and study their effects on the temporal evolution of the core oscillator based Boolean network. Thereby, we attempt to establish a regulatory link between the autonomous cell cycle oscillator and the remainder of the cell. We suggest the unclear yet regulatory effect of phosphorylation on the added components, and discuss many unreported points regarding the temporal evolution of the cell cycle and its components. To better visualize the results regardless of the programming background we developed an Android application that can be used to run the core and extended model of the fission yeast cell cycle step by step.
DOI of the first publication: 10.1371/journal.pone.0208515
URL of the first publication: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208515
Link to this record: hdl:20.500.11880/27755
http://dx.doi.org/10.22028/D291-28867
ISSN: 1932-6203
Date of registration: 12-Sep-2019
Faculty: NT - Naturwissenschaftlich- Technische Fakultät
Department: NT - Biowissenschaften
Professorship: NT - Prof. Dr. Manfred Schmitt
Collections:UniBib – Die Universitätsbibliographie

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