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|Title:||miR-34a: a new player in the regulation of T cell function by modulation of NF-κB signaling|
Friedmann, Kim S.
Schwarz, Eva C.
|Title:||Cell death & disease|
|Publisher/Platform:||Nature Publishing Group|
|Year of Publication:||2019|
|Publikation type:||Journal Article|
|Abstract:||NF-κB functions as modulator of T cell receptor-mediated signaling and transcriptional regulator of miR-34a. Our in silico analysis revealed that miR-34a impacts the NF-κB signalosome with miR-34a binding sites in 14 key members of the NF-κB signaling pathway. Functional analysis identified five target genes of miR-34a including PLCG1, CD3E, PIK3CB, TAB2, and NFΚBIA. Overexpression of miR-34a in CD4+ and CD8+ T cells led to a significant decrease of NFΚBIA as the most downstream cytoplasmic NF-κB member, a reduced cell surface abundance of TCRA and CD3E, and to a reduction of T cell killing capacity. Inhibition of miR-34a caused an increase of NFΚBIA, TCRA, and CD3E. Notably, activation of CD4+ and CD8+ T cells entrails a gradual increase of miR-34a. Our results lend further support to a model with miR-34a as a central NF-κB regulator in T cells.|
|DOI of the first publication:||10.1038/s41419-018-1295-1|
|URL of the first publication:||https://www.nature.com/articles/s41419-018-1295-1|
|Link to this record:||hdl:20.500.11880/27548|
|Date of registration:||17-Jul-2019|
|Faculty:||M - Medizinische Fakultät|
|Department:||M - Infektionsmedizin|
|Professorship:||M - Prof. Dr. Martina Sester|
|Collections:||UniBib – Die Universitätsbibliographie|
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