Please use this identifier to cite or link to this item: doi:10.22028/D291-28057
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Title: miR-34a: a new player in the regulation of T cell function by modulation of NF-κB signaling
Author(s): Hart, Martin
Walch-Rückheim, Barbara
Friedmann, Kim S.
Rheinheimer, Stefanie
Tänzer, Tanja
Glombitza, Birgit
Sester, Martina
Lenhof, Hans-Peter
Hoth, Markus
Schwarz, Eva C.
Keller, Andreas
Meese, Eckart
Language: English
Title: Cell death & disease
Volume: 10
Issue: 2
Startpage: 46
Publisher/Platform: Nature Publishing Group
Year of Publication: 2019
Publikation type: Journal Article
Abstract: NF-κB functions as modulator of T cell receptor-mediated signaling and transcriptional regulator of miR-34a. Our in silico analysis revealed that miR-34a impacts the NF-κB signalosome with miR-34a binding sites in 14 key members of the NF-κB signaling pathway. Functional analysis identified five target genes of miR-34a including PLCG1, CD3E, PIK3CB, TAB2, and NFΚBIA. Overexpression of miR-34a in CD4+ and CD8+ T cells led to a significant decrease of NFΚBIA as the most downstream cytoplasmic NF-κB member, a reduced cell surface abundance of TCRA and CD3E, and to a reduction of T cell killing capacity. Inhibition of miR-34a caused an increase of NFΚBIA, TCRA, and CD3E. Notably, activation of CD4+ and CD8+ T cells entrails a gradual increase of miR-34a. Our results lend further support to a model with miR-34a as a central NF-κB regulator in T cells.
DOI of the first publication: 10.1038/s41419-018-1295-1
URL of the first publication:
Link to this record: hdl:20.500.11880/27548
ISSN: 2041-4889
Date of registration: 17-Jul-2019
Faculty: M - Medizinische Fakultät
Department: M - Infektionsmedizin
Professorship: M - Prof. Dr. Martina Sester
Collections:UniBib – Die Universitätsbibliographie

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