Please use this identifier to cite or link to this item: doi:10.22028/D291-24589
Title: Development of a flexible cell targeting system based on silica nanoparticles
Author(s): Schiestel, Thomas
Schirra, Hermann
Gerwann, Jochen
Lesniak, Christoph P.
Schmidt, Helmut K.
Kalaghi-Nafchi, Abdullah
Sameti, Mohammad
Haltner, Eleonore G.
Lehr, Claus-Michael
Borchard, Gerrit
Language: English
Year of Publication: 1998
OPUS Source: Biomaterials regulating cell function and tissue development : symposium held April 13 - 14, 1998, San Francisco, California, USA / ed.: Robert C. Thomson ... - Warrendale, Pa. : Materials Research Soc., 1998. — (Materials Research Society symposia proceedings ; 530), S. 65-71
SWD key words: Siliciumdioxid
Nanostrukturiertes Material
Chemische Synthese
DDC notations: 620 Engineering and machine engineering
Publikation type: Conference Paper
Abstract: Negatively charged silica nanoparticles are suitable systems to couple various biomolecules while retaining their biological function. A molecular shell consisting of avidin was obtained by binding the molecules to negatively charged particle surfaces through electrostatic interactions. Starting with particles with hydrodynamic diameter of 260 mm, the size increased to 500 mm, while the zeta potential was altered to -8 mV under physiological conditions. Biotinylated wheat germ agglutinin can be coupled to the particle surface through avidin/biotin complex formation. The hydrodynamic diameter increases from 260 nm to 432 nm, while a zeta potential of -28 mV was found under physiological conditions.
Link to this record: urn:nbn:de:bsz:291-scidok-28973
ISBN: 1-558-99436-X
Date of registration: 18-Jun-2010
Faculty: SE - Sonstige Einrichtungen
Department: SE - INM Leibniz-Institut für Neue Materialien
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