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Titel: Differential effects on inhibition of cholesterol absorption by plant stanol and plant sterol esters in apoE−/− mice
Verfasser: Weingärtner , Oliver
Ulrich, Christof
Lütjohann, Dieter
Ismail, Kenan
Schirmer, Stephan
Vanmirlo, Tim
Böhm, Michael
Laufs, Ulrich
Sprache: Deutsch
Erscheinungsjahr: 2011
Quelle: Cardiovascular research. - 2011, DOI: 10.1093/cvr/cvr020 [Elektronische Ressource]
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumentart : Journalartikel
Kurzfassung: Aims 'Functional foods'; supplemented with plant sterol esters (PSE) and plant stanol esters (PSA) are therapeutic options for the management of hypercholesterolaemia. However, their effects on blood monocytes, endothelial function, atherogenesis, and sterol tissue concentrations are poorly understood. Methods and results Male apoE−/− mice (n= 30) were randomized to three different diets for 6 weeks (n= 10 per group): high-cholesterol (1.25%) western-type diet (WTD), WTD + 2% PSE, and WTD + 2% PSA. Both supplements reduced serum cholesterol. WTD + PSE resulted in increased plant sterol serum concentrations and increased inflammatory Ly-6C(high) monocyte numbers. WTD + PSA increased plant stanol serum concentrations and Ly-6C-monocyte numbers, but decreased vascular superoxide release, lipid hydroperoxides, and inflammatory cytokines in aortic tissue, in plasma, and in circulating monocytes. Despite reduced serum cholesterol concentrations, both supplements impaired endothelial vasodilation compared with WTD. WTD + PSA reduced the development of atherosclerotic lesions compared with WTD alone (12.7 ± 3.7 vs. 28.3 ± 3.5%), and WTD + PSE was less effective (17.5 ± 3.7%). WTD + PSE and WTD + PSA reduced the cholesterol content in the liver, but not in the brain. However, WTD + PSE and WTD + PSA increased plant sterol and plant stanol concentrations in the liver as well as in the brain. Conclusion PSE and PSA supplementation reduced serum cholesterol, but increased plant sterol and plant stanol concentrations. Elevated levels of PSE and PSA were associated with endothelial dysfunction and increased central nervous system depositions. Atherosclerotic lesion retardation was more pronounced in WTD + PSA, coinciding with higher regenerative monocyte numbers, decreased oxidative stress, and decreased inflammatory cytokines compared with WTD + PSE.
Link zu diesem Datensatz: urn:nbn:de:bsz:291-scidok-37887
hdl:20.500.11880/21457
http://dx.doi.org/10.22028/D291-21401
SciDok-Publikation: 2-Mai-2011
Fakultät: Fakultät 2 - Medizin
Fachrichtung: M - Innere Medizin
Fakultät / Institution:M - Medizinische Fakultät

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