Please use this identifier to cite or link to this item: doi:10.22028/D291-21401
Title: Differential effects on inhibition of cholesterol absorption by plant stanol and plant sterol esters in apoE−/− mice
Author(s): Weingärtner , Oliver
Ulrich, Christof
Lütjohann, Dieter
Ismail, Kenan
Schirmer, Stephan
Vanmirlo, Tim
Böhm, Michael
Laufs, Ulrich
Language: German
Year of Publication: 2011
OPUS Source: Cardiovascular research. - 2011, DOI: 10.1093/cvr/cvr020 [Elektronische Ressource]
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Aims 'Functional foods'; supplemented with plant sterol esters (PSE) and plant stanol esters (PSA) are therapeutic options for the management of hypercholesterolaemia. However, their effects on blood monocytes, endothelial function, atherogenesis, and sterol tissue concentrations are poorly understood. Methods and results Male apoE−/− mice (n= 30) were randomized to three different diets for 6 weeks (n= 10 per group): high-cholesterol (1.25%) western-type diet (WTD), WTD + 2% PSE, and WTD + 2% PSA. Both supplements reduced serum cholesterol. WTD + PSE resulted in increased plant sterol serum concentrations and increased inflammatory Ly-6C(high) monocyte numbers. WTD + PSA increased plant stanol serum concentrations and Ly-6C-monocyte numbers, but decreased vascular superoxide release, lipid hydroperoxides, and inflammatory cytokines in aortic tissue, in plasma, and in circulating monocytes. Despite reduced serum cholesterol concentrations, both supplements impaired endothelial vasodilation compared with WTD. WTD + PSA reduced the development of atherosclerotic lesions compared with WTD alone (12.7 ± 3.7 vs. 28.3 ± 3.5%), and WTD + PSE was less effective (17.5 ± 3.7%). WTD + PSE and WTD + PSA reduced the cholesterol content in the liver, but not in the brain. However, WTD + PSE and WTD + PSA increased plant sterol and plant stanol concentrations in the liver as well as in the brain. Conclusion PSE and PSA supplementation reduced serum cholesterol, but increased plant sterol and plant stanol concentrations. Elevated levels of PSE and PSA were associated with endothelial dysfunction and increased central nervous system depositions. Atherosclerotic lesion retardation was more pronounced in WTD + PSA, coinciding with higher regenerative monocyte numbers, decreased oxidative stress, and decreased inflammatory cytokines compared with WTD + PSE.
Link to this record: urn:nbn:de:bsz:291-scidok-37887
Date of registration: 2-May-2011
Faculty: M - Medizinische Fakultät
Department: M - Innere Medizin
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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