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Titel: CAPS facilitates filling of the rapidly releasable pool of large dense-core vesicles
Verfasser: Liu, Yuanyuan
Schirra, Claudia
Stevens, David R.
Matti, Ulf
Speidel, Dina
Bruns, Dieter
Brose, Nils
Rettig, Jens
Sprache: Deutsch
Erscheinungsjahr: 2008
Quelle: The journal of neuroscience. - 28. 2008, 21, S. 5594-5601
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumentart : Journalartikel
Kurzfassung: Calcium-activator protein for secretion (CAPS) is a cytosolic protein that associates with large dense-core vesicles and is involved in their secretion. Mammals express two CAPS isoforms, which share a similar domain structure including a Munc13 homology domain that is believed to be involved in the priming of secretory vesicles. A variety of studies designed to perturb CAPS function indicate that CAPS is involved in the secretion of large dense-core vesicles, but where in the secretory pathway CAPS acts is still under debate. Mice in which one allele of the CAPS-1 gene is deleted exhibit a deficit in catecholamine secretion from chromaffin cells. We have examined catecholamine secretion from chromaffin cells in which both CAPS genes were deleted and show that the deletion of both CAPS isoforms causes a strong reduction in the pool of rapidly releasable chromaffin granules and of sustained release during ongoing stimulation. We conclude that CAPS is required for the adequate refilling and/or maintenance of a rapidly releasable granule pool.
Link zu diesem Datensatz: urn:nbn:de:bsz:291-scidok-32888
hdl:20.500.11880/21455
http://dx.doi.org/10.22028/D291-21399
SciDok-Publikation: 2-Mai-2011
Fakultät: Fakultät 2 - Medizin
Fachrichtung: M - Physiologie
Fakultät / Institution:M - Medizinische Fakultät

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