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Titel: The relationships of markers of cholesterol homeostasis with carotid intima-media thickness
Verfasser: Weingärtner, Oliver
Pinsdorf, Tobias
Rogacev, Kyrill S.
Blömer, Lutz
Grenner, Yvonne
Gräber, Stefan
Ulrich, Christof
Girndt, Matthias
Böhm, Michael
Fliser, Danilo
Laufs, Ulrich
Lütjohann, Dieter
Heine, Gunnar, H.
Sprache: Deutsch
Erscheinungsjahr: 2010
Quelle: PLoS one. - 5. 2010, 10, e13467 [Elektronische Ressource]
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumentart : Journalartikel
Kurzfassung: Background: The relationship of cholesterol homeostasis and carotid intima-media thickness (cIMT) is unknown. To address this, we assessed markers of cholesterol homeostasis (serum plant sterols and cholesterol precursor concentrations as surrogate measures of cholesterol absorption and synthesis, respectively) and cIMT in a middle-aged, statin-naive population. Methods: In this prospective study of primary prevention cIMT was measured by ultrasound in 583 hospital employees aged 25—60 years without prevalent cardiovascular disease or lipid-modifying medication. The serum concentrations of plant sterols (as markers of cholesterol absorption) were measured by gas-liquid chromatography. Lathosterol serum concentrations were quantitated to assess hepatic cholesterol synthesis. Results: cIMT correlated positively with serum cholesterol (r = 0.22, P,0.0005) and lathosterol-to-cholesterol (r = 0.18, P,0.001). In contrast, plant sterols, as markers of cholesterol absorption, showed a weak negative correlation to cIMT measurements (r =20.18; P,0.001 for campesterol-to-cholesterol). Stratifying subjects by serum sterol levels, we found that cIMT increased continuously over quintiles of serum cholesterol (P,0.0005) and was positively associated to serum lathosterol-to-cholesterol levels (P=0.007), on the other hand, plant sterol levels showed a weak negative association to cIMT (P,0.001 for campesterol-to-cholesterol). Conclusions: In this population without prevalent cardiovascular diseases or lipid-modifying medication, markers of increased endogenous cholesterol synthesis correlated positively with cIMT, while markers of cholesterol absorption showed a weakly negative correlation. These data suggest that not only total serum cholesterol levels but also differences in cholesterol homeostasis are associated with cIMT.
Link zu diesem Datensatz: urn:nbn:de:bsz:291-scidok-33924
hdl:20.500.11880/21372
http://dx.doi.org/10.22028/D291-21316
SciDok-Publikation: 27-Okt-2010
Fakultät: Fakultät 2 - Medizin
Fakultät 2 - Medizin
Fachrichtung: M - Innere Medizin
M - Medizinische Biometrie, Epidemiologie und medizinische Informatik
Ehemalige Fachrichtung: bis SS 2016: Fachrichtung 2.29 - Medizinische Biometrie, Epidemiologie und Medizinische Informatik
Fakultät / Institution:M - Medizinische Fakultät

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