Please use this identifier to cite or link to this item: doi:10.22028/D291-21004
Title: Gene therapy for articular cartilage repair
Author(s): Trippel, Stephen
Cucchiarini, Magali
Madry, Henning
Shi , S.
Wang, C.
Language: German
Year of Publication: 2007
OPUS Source: Proceedings of the Institution of Mechanical Engineers / H. - 221. 2007, 5, S. 451-459
DDC notations: 610 Medicine and health
Publikation type: Journal Article
Abstract: Articular cartilage serves as the gliding surface of joints. It is susceptible to damage from trauma and from degenerative diseases. Restoration of damaged articular cartilage may be achievable through the use of cell-regulatory molecules that augment the reparative activities of the cells, inhibit the cells'; degradative activities, or both. A variety of such molecules have been identified. These include insulin-like growth factor I, fibroblast growth factor 2, bone morphogenetic proteins 2, 4, and 7, and interleukin-1 receptor antagonist. It is now possible to transfer the genes encoding such molecules into articular cartilage and synovial lining cells. Although preliminary, data from in-vitro and in-vivo studies suggest that gene therapy can deliver such potentially therapeutic agents to protect existing cartilage and to build new cartilage. Keywords: gene therapy, vectors, articular cartilage, arthritis, animal models
Link to this record: urn:nbn:de:bsz:291-scidok-15063
Date of registration: 29-Apr-2008
Faculty: M - Medizinische Fakultät
Department: M - Orthopädie
Collections:SciDok - Der Wissenschaftsserver der Universität des Saarlandes

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