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Titel: Gene therapy for articular cartilage repair
Verfasser: Trippel, Stephen
Cucchiarini, Magali
Madry, Henning
Shi , S.
Wang, C.
Sprache: Deutsch
Erscheinungsjahr: 2007
Quelle: Proceedings of the Institution of Mechanical Engineers / H. - 221. 2007, 5, S. 451-459
DDC-Sachgruppe: 610 Medizin, Gesundheit
Dokumentart : Journalartikel
Kurzfassung: Articular cartilage serves as the gliding surface of joints. It is susceptible to damage from trauma and from degenerative diseases. Restoration of damaged articular cartilage may be achievable through the use of cell-regulatory molecules that augment the reparative activities of the cells, inhibit the cells'; degradative activities, or both. A variety of such molecules have been identified. These include insulin-like growth factor I, fibroblast growth factor 2, bone morphogenetic proteins 2, 4, and 7, and interleukin-1 receptor antagonist. It is now possible to transfer the genes encoding such molecules into articular cartilage and synovial lining cells. Although preliminary, data from in-vitro and in-vivo studies suggest that gene therapy can deliver such potentially therapeutic agents to protect existing cartilage and to build new cartilage. Keywords: gene therapy, vectors, articular cartilage, arthritis, animal models
Link zu diesem Datensatz: urn:nbn:de:bsz:291-scidok-15063
hdl:20.500.11880/21060
http://dx.doi.org/10.22028/D291-21004
SciDok-Publikation: 29-Apr-2008
Fakultät: Fakultät 2 - Medizin
Fachrichtung: M - Orthopädie
Fakultät / Institution:M - Medizinische Fakultät

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