%PDF-1.4
%
1 0 obj
<<
/Names 2 0 R
/Outlines 3 0 R
/Metadata 4 0 R
/Pages 5 0 R
/Type /Catalog
/PageLabels 6 0 R
>>
endobj
7 0 obj
<<
/CreationDate (D:20221220193723+05'30')
/Creator (Arbortext Advanced Print Publisher 9.1.510/W Unicode)
/Producer (Acrobat Distiller 7.0 \(Windows\))
/ModDate (D:20221220193723+05'30')
>>
endobj
2 0 obj
<<
/Dests 8 0 R
>>
endobj
3 0 obj
<<
/First 9 0 R
/Count 1
/Last 9 0 R
>>
endobj
4 0 obj
<<
/Type /Metadata
/Subtype /XML
/Length 10 0 R
>>
stream
dvips + MiKTeX GPL Ghostscript 9.0
Sec62, prognostic, therapy, ovarian cancer, borderline tumors of the ovary, tumor driver mutation, 3q26 amplification
Effect of the 3q26-coding oncogene SEC62 as a potential prognostic marker in patients with ovarian neoplasia
Julia C. Radosa
Mariz Kasoha
Anne-Christine Schilz
Zoltan F. Takacs
Askin Kaya
Marc P. Radosa
Barbara Linxweiler
Maximilian Linxweiler
Rainer M. Bohle
Mathias Wagner
Gudrun Wagenpfeil
Erich-Franz Solomayer
Julia S. M. Zimmermann
With approximately 220,000 newly diagnosed cases per year, ovarian cancer is among the most frequently occurring cancers among women and the second leading cause of death from gynecological malignancies worldwide.
Sec62prognostictherapyovarian cancerborderline tumors of the ovarytumor driver mutation3q26 amplification
false
false
endstream
endobj
5 0 obj
<<
/Count 11
/Type /Pages
/Kids [11 0 R 12 0 R]
>>
endobj
6 0 obj
<<
/Nums [0 13 0 R]
>>
endobj
8 0 obj
<<
/Kids [14 0 R 15 0 R]
>>
endobj
9 0 obj
<<
/First 16 0 R
/Parent 3 0 R
/Dest
/Count -13
/Last 17 0 R
/Title
>>
endobj
10 0 obj
3321
endobj
11 0 obj
<<
/Parent 5 0 R
/Count 10
/Type /Pages
/Kids [18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R]
>>
endobj
12 0 obj
<<
/Parent 5 0 R
/Count 1
/Type /Pages
/Kids [28 0 R]
>>
endobj
13 0 obj
<<
/S /D
>>
endobj
14 0 obj
<<
/Limits [ ]
/Names [ 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R
34 0 R 35 0 R 36 0 R 37 0 R 38 0 R
39 0 R 40 0 R 41 0 R 42 0 R 43 0 R
44 0 R 45 0 R 46 0 R 47 0 R 48 0 R
49 0 R 50 0 R 51 0 R 52 0 R 53 0 R
54 0 R 55 0 R 56 0 R 57 0 R 58 0 R
59 0 R 60 0 R 61 0 R 62 0 R 63 0 R
64 0 R 65 0 R 66 0 R 67 0 R 68 0 R
69 0 R 70 0 R 71 0 R 72 0 R 73 0 R
74 0 R 75 0 R 76 0 R 77 0 R 78 0 R
79 0 R 80 0 R 81 0 R 82 0 R 83 0 R
84 0 R 85 0 R 86 0 R 87 0 R 88 0 R
89 0 R 90 0 R 91 0 R 92 0 R]
>>
endobj
15 0 obj
<<
/Limits [ ]
/Names [ 93 0 R 94 0 R 95 0 R 96 0 R 97 0 R
98 0 R 99 0 R 100 0 R 101 0 R 102 0 R]
>>
endobj
16 0 obj
<<
/Parent 9 0 R
/Next 103 0 R
/Dest
/Title
>>
endobj
17 0 obj
<<
/Parent 9 0 R
/Dest
/Prev 104 0 R
/Title
>>
endobj
18 0 obj
<<
/CropBox [0 0 595.2760009766 841.8900146484]
/Annots [105 0 R 106 0 R 107 0 R 108 0 R 109 0 R 110 0 R 111 0 R 112 0 R 113 0 R 114 0 R
115 0 R 116 0 R 117 0 R 118 0 R 119 0 R 120 0 R]
/Parent 11 0 R
/Contents [121 0 R 122 0 R 123 0 R 124 0 R 125 0 R 126 0 R 127 0 R 128 0 R]
/Rotate 0
/MediaBox [0 0 595.2760009766 841.8900146484]
/Thumb 129 0 R
/Resources 130 0 R
/Type /Page
>>
endobj
19 0 obj
<<
/CropBox [0 0 595.2760009766 841.8900146484]
/Annots [131 0 R 132 0 R 133 0 R 134 0 R 135 0 R 136 0 R 137 0 R 138 0 R 139 0 R 140 0 R
141 0 R 142 0 R 143 0 R 144 0 R 145 0 R 146 0 R 147 0 R 148 0 R 149 0 R 150 0 R
151 0 R 152 0 R 153 0 R 154 0 R 155 0 R 156 0 R 157 0 R 158 0 R 159 0 R 160 0 R
161 0 R 162 0 R 163 0 R 164 0 R]
/Parent 11 0 R
/Contents 165 0 R
/Rotate 0
/MediaBox [0 0 595.2760009766 841.8900146484]
/Thumb 166 0 R
/Resources 167 0 R
/Type /Page
>>
endobj
20 0 obj
<<
/CropBox [0 0 595.2760009766 841.8900146484]
/Annots [168 0 R 169 0 R 170 0 R 171 0 R 172 0 R 173 0 R 174 0 R 175 0 R 176 0 R 177 0 R
178 0 R 179 0 R 180 0 R 181 0 R 182 0 R]
/Parent 11 0 R
/Contents 183 0 R
/Rotate 0
/MediaBox [0 0 595.2760009766 841.8900146484]
/Thumb 184 0 R
/Resources 185 0 R
/Type /Page
>>
endobj
21 0 obj
<<
/CropBox [0 0 595.2760009766 841.8900146484]
/Annots [186 0 R 187 0 R 188 0 R]
/Parent 11 0 R
/Contents 189 0 R
/Rotate 0
/MediaBox [0 0 595.2760009766 841.8900146484]
/Thumb 190 0 R
/Resources 191 0 R
/Type /Page
>>
endobj
22 0 obj
<<
/CropBox [0 0 595.2760009766 841.8900146484]
/Annots [192 0 R 193 0 R 194 0 R 195 0 R 196 0 R 197 0 R 198 0 R 199 0 R 200 0 R 201 0 R
202 0 R 203 0 R 204 0 R 205 0 R 206 0 R 207 0 R 208 0 R 209 0 R 210 0 R 211 0 R
212 0 R]
/Parent 11 0 R
/Contents 213 0 R
/Rotate 0
/MediaBox [0 0 595.2760009766 841.8900146484]
/Thumb 214 0 R
/Resources 215 0 R
/Type /Page
>>
endobj
23 0 obj
<<
/CropBox [0 0 595.2760009766 841.8900146484]
/Annots [216 0 R 217 0 R 218 0 R 219 0 R]
/Parent 11 0 R
/Contents 220 0 R
/Rotate 0
/MediaBox [0 0 595.2760009766 841.8900146484]
/Thumb 221 0 R
/Resources 222 0 R
/Type /Page
>>
endobj
24 0 obj
<<
/CropBox [0 0 595.2760009766 841.8900146484]
/Annots [223 0 R 224 0 R 225 0 R 226 0 R 227 0 R 228 0 R 229 0 R 230 0 R 231 0 R 232 0 R
233 0 R 234 0 R 235 0 R 236 0 R 237 0 R]
/Parent 11 0 R
/Contents 238 0 R
/Rotate 0
/MediaBox [0 0 595.2760009766 841.8900146484]
/Thumb 239 0 R
/Resources 240 0 R
/Type /Page
>>
endobj
25 0 obj
<<
/CropBox [0 0 595.2760009766 841.8900146484]
/Annots [241 0 R 242 0 R 243 0 R]
/Parent 11 0 R
/Contents 244 0 R
/Rotate 0
/MediaBox [0 0 595.2760009766 841.8900146484]
/Thumb 245 0 R
/Resources 246 0 R
/Type /Page
>>
endobj
26 0 obj
<<
/CropBox [0 0 595.2760009766 841.8900146484]
/Annots [247 0 R 248 0 R 249 0 R]
/Parent 11 0 R
/Contents 250 0 R
/Rotate 0
/MediaBox [0 0 595.2760009766 841.8900146484]
/Thumb 251 0 R
/Resources 252 0 R
/Type /Page
>>
endobj
27 0 obj
<<
/CropBox [0 0 595.2760009766 841.8900146484]
/Annots [253 0 R 254 0 R 255 0 R 256 0 R 257 0 R 258 0 R 259 0 R 260 0 R 261 0 R 262 0 R
263 0 R 264 0 R 265 0 R 266 0 R 267 0 R 268 0 R 269 0 R]
/Parent 11 0 R
/Contents 270 0 R
/Rotate 0
/MediaBox [0 0 595.2760009766 841.8900146484]
/Thumb 271 0 R
/Resources 272 0 R
/Type /Page
>>
endobj
28 0 obj
<<
/CropBox [0 0 595.2760009766 841.8900146484]
/Annots [273 0 R 274 0 R 275 0 R 276 0 R 277 0 R 278 0 R 279 0 R 280 0 R 281 0 R 282 0 R
283 0 R 284 0 R 285 0 R 286 0 R 287 0 R 288 0 R 289 0 R 290 0 R 291 0 R 292 0 R
293 0 R 294 0 R 295 0 R]
/Parent 12 0 R
/Contents 296 0 R
/Rotate 0
/MediaBox [0 0 595.2760009766 841.8900146484]
/Thumb 297 0 R
/Resources 298 0 R
/Type /Page
>>
endobj
29 0 obj
<<
/D [27 0 R /XYZ 57 316 null]
>>
endobj
30 0 obj
<<
/D [27 0 R /XYZ 309 232 null]
>>
endobj
31 0 obj
<<
/D [27 0 R /XYZ 309 205 null]
>>
endobj
32 0 obj
<<
/D [27 0 R /XYZ 309 177 null]
>>
endobj
33 0 obj
<<
/D [27 0 R /XYZ 309 149 null]
>>
endobj
34 0 obj
<<
/D [27 0 R /XYZ 309 129 null]
>>
endobj
35 0 obj
<<
/D [28 0 R /XYZ 57 761 null]
>>
endobj
36 0 obj
<<
/D [28 0 R /XYZ 57 726 null]
>>
endobj
37 0 obj
<<
/D [28 0 R /XYZ 57 682 null]
>>
endobj
38 0 obj
<<
/D [28 0 R /XYZ 57 646 null]
>>
endobj
39 0 obj
<<
/D [28 0 R /XYZ 57 610 null]
>>
endobj
40 0 obj
<<
/D [27 0 R /XYZ 57 280 null]
>>
endobj
41 0 obj
<<
/D [28 0 R /XYZ 57 582 null]
>>
endobj
42 0 obj
<<
/D [28 0 R /XYZ 57 546 null]
>>
endobj
43 0 obj
<<
/D [28 0 R /XYZ 309 761 null]
>>
endobj
44 0 obj
<<
/D [28 0 R /XYZ 309 734 null]
>>
endobj
45 0 obj
<<
/D [28 0 R /XYZ 309 714 null]
>>
endobj
46 0 obj
<<
/D [28 0 R /XYZ 309 678 null]
>>
endobj
47 0 obj
<<
/D [28 0 R /XYZ 309 650 null]
>>
endobj
48 0 obj
<<
/D [28 0 R /XYZ 309 622 null]
>>
endobj
49 0 obj
<<
/D [28 0 R /XYZ 309 586 null]
>>
endobj
50 0 obj
<<
/D [28 0 R /XYZ 309 550 null]
>>
endobj
51 0 obj
<<
/D [27 0 R /XYZ 57 244 null]
>>
endobj
52 0 obj
<<
/D [27 0 R /XYZ 57 209 null]
>>
endobj
53 0 obj
<<
/D [27 0 R /XYZ 57 173 null]
>>
endobj
54 0 obj
<<
/D [27 0 R /XYZ 57 145 null]
>>
endobj
55 0 obj
<<
/D [27 0 R /XYZ 309 316 null]
>>
endobj
56 0 obj
<<
/D [27 0 R /XYZ 309 288 null]
>>
endobj
57 0 obj
<<
/D [27 0 R /XYZ 309 260 null]
>>
endobj
58 0 obj
<<
/D [21 0 R /XYZ 69 490 null]
>>
endobj
59 0 obj
<<
/D [21 0 R /XYZ 69 187 null]
>>
endobj
60 0 obj
<<
/D [25 0 R /XYZ 69 176 null]
>>
endobj
61 0 obj
<<
/D [26 0 R /XYZ 69 176 null]
>>
endobj
62 0 obj
<<
/D [22 0 R /XYZ 57 762 null]
>>
endobj
63 0 obj
<<
/D [23 0 R /XYZ 57 762 null]
>>
endobj
64 0 obj
<<
/D [23 0 R /XYZ 57 455 null]
>>
endobj
65 0 obj
<<
/D [24 0 R /XYZ 57 762 null]
>>
endobj
66 0 obj
<<
/D [19 0 R /XYZ 0 842 null]
>>
endobj
67 0 obj
<<
/D [27 0 R /XYZ 0 842 null]
>>
endobj
68 0 obj
<<
/D [27 0 R /XYZ 0 842 null]
>>
endobj
69 0 obj
<<
/D [19 0 R /XYZ 0 842 null]
>>
endobj
70 0 obj
<<
/D [20 0 R /XYZ 0 842 null]
>>
endobj
71 0 obj
<<
/D [23 0 R /XYZ 0 842 null]
>>
endobj
72 0 obj
<<
/D [24 0 R /XYZ 0 842 null]
>>
endobj
73 0 obj
<<
/D [27 0 R /XYZ 0 842 null]
>>
endobj
74 0 obj
<<
/D [27 0 R /XYZ 0 842 null]
>>
endobj
75 0 obj
<<
/D [27 0 R /XYZ 0 842 null]
>>
endobj
76 0 obj
<<
/D [27 0 R /XYZ 0 842 null]
>>
endobj
77 0 obj
<<
/D [27 0 R /XYZ 0 842 null]
>>
endobj
78 0 obj
<<
/D [19 0 R /XYZ 57 664 null]
>>
endobj
79 0 obj
<<
/D [27 0 R /XYZ 309 540 null]
>>
endobj
80 0 obj
<<
/D [27 0 R /XYZ 309 453 null]
>>
endobj
81 0 obj
<<
/D [19 0 R /XYZ 309 341 null]
>>
endobj
82 0 obj
<<
/D [19 0 R /XYZ 309 316 null]
>>
endobj
83 0 obj
<<
/D [20 0 R /XYZ 57 689 null]
>>
endobj
84 0 obj
<<
/D [20 0 R /XYZ 309 702 null]
>>
endobj
85 0 obj
<<
/D [20 0 R /XYZ 309 577 null]
>>
endobj
86 0 obj
<<
/D [20 0 R /XYZ 309 328 null]
>>
endobj
87 0 obj
<<
/D [22 0 R /XYZ 57 419 null]
>>
endobj
88 0 obj
<<
/D [22 0 R /XYZ 309 270 null]
>>
endobj
89 0 obj
<<
/D [23 0 R /XYZ 57 262 null]
>>
endobj
90 0 obj
<<
/D [24 0 R /XYZ 309 178 null]
>>
endobj
91 0 obj
<<
/D [27 0 R /XYZ 57 702 null]
>>
endobj
92 0 obj
<<
/D [27 0 R /XYZ 57 615 null]
>>
endobj
93 0 obj
<<
/D [27 0 R /XYZ 57 527 null]
>>
endobj
94 0 obj
<<
/D [27 0 R /XYZ 309 764 null]
>>
endobj
95 0 obj
<<
/D [19 0 R /XYZ 0 842 null]
>>
endobj
96 0 obj
<<
/D [20 0 R /XYZ 0 842 null]
>>
endobj
97 0 obj
<<
/D [20 0 R /XYZ 0 842 null]
>>
endobj
98 0 obj
<<
/D [20 0 R /XYZ 0 842 null]
>>
endobj
99 0 obj
<<
/D [22 0 R /XYZ 0 842 null]
>>
endobj
100 0 obj
<<
/D [22 0 R /XYZ 0 842 null]
>>
endobj
101 0 obj
<<
/D [27 0 R /XYZ 0 842 null]
>>
endobj
102 0 obj
<<
/D [18 0 R /XYZ 0 842 null]
>>
endobj
103 0 obj
<<
/First 299 0 R
/Parent 9 0 R
/Next 300 0 R
/Dest
/Count -4
/Last 301 0 R
/Prev 16 0 R
/Title
>>
endobj
104 0 obj
<<
/Parent 9 0 R
/Next 17 0 R
/Dest
/Prev 302 0 R
/Title
>>
endobj
105 0 obj
<<
/Rect [222.5200042725 685.757019043 475.0859985352 706.6770019531]
/Subtype /Link
/A 303 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
106 0 obj
<<
/Rect [222.5200042725 660.8690185547 526.2239990234 681.7890014648]
/Subtype /Link
/A 304 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
107 0 obj
<<
/Rect [222.5200042725 635.9240112305 508.8190002441 656.8439941406]
/Subtype /Link
/A 305 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
108 0 obj
<<
/Rect [222.5200042725 611.0360107422 439.3699951172 631.9559936523]
/Subtype /Link
/A 306 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
109 0 obj
<<
/Rect [56.6930007935 691.6530151367 128.6360015869 705.8270263672]
/Subtype /Link
/A 307 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
110 0 obj
<<
/Rect [56.6930007935 541.133972168 61.0579986572 544.7620239258]
/Subtype /Link
/A 308 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
111 0 obj
<<
/Rect [63.0989990234 539.4329833984 124.1009979248 546.4060058594]
/Subtype /Link
/A 309 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
112 0 obj
<<
/Rect [71.0360031128 343.6719970703 163.2189941406 350.6459960938]
/Subtype /Link
/A 310 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
113 0 obj
<<
/Rect [98.4189987183 275.4710083008 160.2140045166 282.4440002441]
/Subtype /Link
/A 311 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
114 0 obj
<<
/Rect [56.6930007935 266.4570007324 143.2630004883 273.4299926758]
/Subtype /Link
/A 312 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
115 0 obj
<<
/Rect [56.6930007935 40.7620010376 130.2239990234 47.7350006104]
/Subtype /Link
/A 313 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
116 0 obj
<<
/Rect [492.8880004883 40.7620010376 538.5830078125 47.7350006104]
/Subtype /Link
/A 314 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
117 0 obj
<<
/Rect [56.6930007935 780.8309936523 231.4199981689 794.833984375]
/Subtype /Link
/A 315 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
118 0 obj
<<
/Rect [433.9840087891 792.9639892578 446.967010498 798.4630126953]
/Subtype /Link
/A 316 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
119 0 obj
<<
/Rect [446.967010498 792.6229858398 505.4169921875 799.5969848633]
/Subtype /Link
/A 317 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
120 0 obj
<<
/Rect [446.3999938965 774.6519775391 538.5830078125 781.625]
/Subtype /Link
/A 318 0 R
/Border [0 0 0]
/Type /Annot
>>
endobj
121 0 obj
<<
/Length 319 0 R
/Filter /FlateDecode
>>
stream
HWnFž+%@+}g1-:,j)~&fQvCO:Uͥܵ'W'/.DLnO$O2) ǿa-LfxVINx
h&mQUAO[_tSTVuscꓴӢ鿮~ľH˫W'WT@5"1|?Jw6fy;8²U+Ep8utf+ɱe~ (\UޕIEV<=<ٰ!oMIqrbRCi=,QIEǐY)\r
aЁ*K~{1G%41$&
;?Veyz^ "%nH+a.ݼ$Uk~WXP|.E)$Eb߉䤳oֳf]/@Yˁ )WзɁԌ~ݔ|zxp.E7g7ZG@}A,vt\.}̫j,6KNPCc6aN8jxX'\!,_%W~TS=7*SF7Uz9
һP}i;!4 MY 5":ԯ>zt|lQl]tu0@
[fմnڲ
ovUv,)(tUToͺ.eIJG S&dfCGOY4Jd$` إc@/Vpp0=wt-4Ga:;O-ʪ_!QKz#ahWӟfփ'4*}쫳>#`[DgXvШ&:Zd;D40F6fCW7-[ͦ#J?|ܗe<-Xg_Gn*v fbJ%"nj%r3$BMwIGqFUCk0DWJB@2,cWi4gԂxBíc l$ALڱJR(8j$-өMP{3#29J=][82y
DEIûJEgR<6tzBLr^ʙ_5\[IzճOfp[CE!,no-쨊ܻMLe]E5 ظ54a6" X])NG=P@ӞpY{D~EGE]pInSŎM}q/ʻ
qC)BkG7pSBNᇠ7@0,7Wm(v{.Sػw!:NEq#(* ,L
%OPJ)3SbP,5M1s]7C@ÔfMtBBQl8<0@[c4z|GK^}XW# PV5}2Z1*#:O9o=j,D$Wy4y+cqvpۺXAX]
Caٵaڥi߇JvRKvU]cc" aE,#p"( ѽƱe9͌%mC5CrxUmy ڔ4.42A\ ϓGp
ƎR}|gx_ƴJM+g7b3%ThNi:^?NE?(Q%"n3mW8 `,3
`4<Pm5q-[|{\}ƄY2dz5C7.;.&IZZe%_(A՜)ڐ*Tk{D7{v@{o_Zy35[gd$q^R(tF@r}H!0HE#"@F5~:Ma|4Y_TZRQm -Զ?SWC>mm&AT 6zH7ؠB(&ei)!]AYdQ,MAsN;#: E